Dr. Huaqiong Li
Wenzhou institute, UCAS
Heterogeneous tissue repair material is a potential implant material. Hyperacute rejection (HAR) will happen when transferring porcine tissues into primates, which is caused by α1, 3-galactose (α1, 3 Gal). The enzyme α1, 3-galactosyltransferase (α1, 3 GT) synthesizes α1, 3 Gal epitopes on the cell surface. In order to avoid the occurrence of immune rejection, the experimental materials selected by our group are from α - 1,3-galactosidase (GGTA1) gene knockout pigs, which can reduce the rejection between the implant and the host as much as possible. In addition, using the principles and methods of tissue engineering to construct the graft, provides a new idea and method for the repair of tissue defects. In our research group, we combined the acellular matrix and polymer to construct bone, cartilage and tympanic membrane repair tissue engineering scaffolds with excellent mechanical properties and cellular biological properties by 3D printing and other technologies. The structure and performance of scaffolds are used to control the in situ growth of cells and the entry and maintenance of specific types of development pathway of cells around the defect site in vivo, and finally to form healthy tissue with morphology and function.
At present, there are 3 PhDs, 2 Research Assistants and 3 postgraduate students in the research group. Dr. Li Huaqiong, leader of the research group, was selected into the China-Australia Young Scientist Exchange Program of the Ministry of Science and Technology in 2019 and the 580 Overseas Elite Program of Wenzhou City. He has published more than 20 SCI papers in biomaterials related journals (such as ACS Applied Materials and Interfaces, Acta Biomaterialia, Chemical Engineering Journal, Journal of Materials Chemistry B, etc.). After joining the Institute in 2015, he has granted five projects at the national, provincial and municipal levels (with a total of more than 5 million). He has applied for 6 patents (with one authorized). He was also supported by the exchange program of the Ninth Regular Session of the China-Croatia Science and Technology Cooperation Commission of the Ministry of Science and Technology.
Gene knockout pigs and 3D printing technology are applied to construct xenogeneic tissue repair materials.
Various techniques are used to modify the surface of biomaterials to study cell-material interactions. Mainly focusing on the influence of the physical properties on the cell growth (e.g. cell differentiation and cell aging).
Constructing nanodrug delivery systems for cancer and other diseases.