Dr. Changcan Shi
Wenzhou institute, UCAS
It builds on the foundation of Wenzhou Institute of Biomaterials and Engineering (WIBE) and School of Chemical Engineering, Tianjin University. Taking advantage of respective scientific research strength, Biomedical Polymers Joint Engineering Research Center devotes to develop hemostasis and wound dressing with smart environment response property.
The main research interests of Biomedical Polymers Joint Engineering Research Center include construction of gene carrier, design of drug release system, and customized synthesis of commercial medical products. At present, our hemostatic products have passed the preliminary biosafety certification of China Food and Drug Testing Institute.
Scientific Research Progress
Uncontrolled bleeding causes more than 30% of traumatic deaths, more than half of which occur before emergency care arrives. The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body’s own coagulation process is not able to accomplish hemostasis timely without the assistance of hemostatic agents. To this end, we develop various kinds of hemostatic materials.
To irregular wound in vivo, we design “lotus seedpod surface-like” polysaccharide hemostatic microspheres (PHMs), which have “macro-pits on surface” morphology and “micropores in macro-pits” structure using an easy and feasible inverse emulsion polymerization method. Owing to the special surface morphology and internal structure, PHM4 demonstrated to have excellent properties in water absorption ability and quick hemostatic performance. We believe that PHM4 will be a suitable hemostatic product in the future clinical application as an effective wound dressing. Related research results were published as “Polysaccharide based “lotus seedpod surface-like” porous microsphere with precise and controllable micromorphology for ultrarapid hemostasis” in ACS Appl. Mater. Interfaces. (ACS applied materials & interfaces, 2019, 11(50): 46558-46571.)
For uncontrolled and noncompressible hemorrhage, we develop a rapid shape recovery material with both active and passive hemostatic performance, a dual-functional hemostatic sponge (TRAP-Sp) with amacroporous structure and good mechanical properties for controlling massive and noncompressible hemorrhage was prepared by chemically immobilizing thrombin-receptor-agonist-peptide (TRAP) onto a starch/polyethylene glycol (PEG) sponge. After absorbing water, the shape-fixed TRAP-Sp with sufficient mechanical strength and high resilience can rapidly expand and apply pressure to the wound. With excellent hemostatic performance and biosafety, this sponge could be a potential candidate as a topical hemostatic agent for uncontrolled and non-compressible hemorrhage. Related research results were published as “Peptide-immobilized starch/PEG sponge with rapid shape recovery and dual-function for both uncontrolled and noncompressible hemorrhage” in Acta Biomaterialia. (Acta biomaterialia, 2019, 99: 220-235.)