Shu Yaogen’s Lab


Dr. Yaogen Shu
Principal Investigator
Wenzhou institute, UCAS
Email:shuyaogen@wiucas.ac.cn

Introduction: From Feb. 2020 to now, he has worked at the Wenzhou Institute of UCAS, and focused on Physical Biology and the highly sensitive detection of Biofluorescence. His research work has been supported by National Basic Research Program of China (973), National Natural Science Foundation of China, Key Research Program of Frontier Sciences of CAS,and the CAS Strategic Priority Research Program etc. He has published more than 40 articles in international Journals, written two chapters in English Books, and translated 4 Biophysical books. His research work has been invited to report ten times at international conferences. Among them, the rotary motor sensor based on F1Fo-ATPase win the 1st Prize of "Biosensors and Bioelectronics" for the most original contribution in the 24th World Conference on Biosensors (Biosensor 2014, Melbourne). Since 2012, he has been invited to give oral presentations and has chaired a Session at the "International Conference on Biomedical Engineering Systems and Technologies" (BIOSTEC) held in Vilamoura, Rome, Funchal, Prague, and Valletta respectively. He is a member of the Standing Committee of the Tumor Metabolism Committee of the Chinese Anti-Cancer Association; he has been granted three invention patents for high-sensitivity and rapid detection.

Research Field
A: Physical biology: kinetics of virus packaging, kinetics of high-fidelity of DNA replication, dynamics of cell energy metabolic, system kinetics of rotary motor ATP synthase, mechanism of mechanochemical coupling of processive motors, cooperative dynamics of collective motor, active Brownian motion, etc
B: High-sensitivity detection of Biofluorescence: high-sensitivity detection of fluorescence in lateral flow assay; quantitative detection of large-area fluorescent signals; determination of pathways of cell energy metabolism; inactivation of virus without secondary pollution; application of molecular motor sensors, etc.

Research Achievements
1. The relation between the speed of F1Fo-ATPase and the concentration of substrates, and p.m.f

JPCB.112(2008)13453

 

2. Highly sensitive detector assembled by rotary motor.

BIOSTEC2016, DOI: 10.5220/0005692301660169

3. Kinetics of high-fidelity of DNA replication:
(JPCM.27(2015)235105/29(2017)025101, PRE.100(2019)012131)

4. Translations:
 

5. Award and Chair of international Conferences:
 

6. Equipments:
(1) POCT of near-infrared fluorescence:

(ZL 2012 1 0269298.7)

(2) quantitative detection of large-area fluorescent signals:

(ZL 2010 1 0500897.6)

(3) Detector of the kinetics of ATP synthesis/hydrolysis:

(ZL 2010 1 0500893.8)
 
Other Groups