Functional nanomaterials group

Dr. Yunlong Zhou
Principal Investigator
Wenzhou institute, UCAS
Tel: +86-577-88017537

Professor Yunlong Zhou received his PhD degree from National Center for Nanoscience and Nanotechnology, Chinese Academy of Sciences (2010). Then he worked in Department of Chemical Engineering, University of Michigan and Department of Nanomedicine, Houston Methodist Hospital as a postdoctoral researcher (2010 ˗ 2014). His research explores the self-assembly of inorganic nanoparticles, biointerface between nanomaterials and biomolecule, and bio-related flexible devices. He has published over 30 papers in peer-reviewed international journals (such as Nature Communications, Journal of American Chemical Society, Angewandte Chemie International Edition, ACS Nano). His work has been cited more than 2000 times.

Our Research
Our research group has been focusing on synthesis and bio-inspired self-assembly of medical function materials, including inorganic materials, supramolecular materials, and inorganic-macromolecular composite intelligent sensing materials. We have proposed an inorganic tetrahedral model and dynamic multipoint bonding model of mesoscopic scale and elaborate the interaction mechanism between materials and biomolecules by a variety of analysis methods and molecular dynamics simulation. The preparation strategy and theoretical models of high viscoelastic inorganic hydrogel were also systematically studied to apply in biosensors. Combined with clinical requirements, we have developed a series of flexible portable electronic devices which can be used for health monitoring and medical diagnosis, in order to explore the application in aspects of real-time monitoring of cytometry, sign language recognition, pulse manifestation, and VR equipment for stroke rehabilitation. The sources of scientific research funds were the National Natural Science Foundation, National Health Commission Foundation, Natural Science Foundation of Zhejiang Province, and Research Institute Major Projects, etc. Since 2016, more than 20 refereed journal publications published in Nature Communications, ACS nano,Chemical Science etc. (citations 2100), and 26 patents have been granted.

Research Topics
1)Biomimetic self-assembly of functional nanocomposite biomaterials, including chiral-related induced effect, interface chemistry and viscoelastic composite self-assembly materials;
2)Application of supramolecular self-assembly system in tissue repair. Design and synthesis of biomimetic peptides and short peptides and their application in antibacterial, bone tissue and neural tissue regeneration;
3)Design flexible sensing materials for medical treatment and health, including ultra-sensing flexible chips and intelligent real-time sensing system.

[1] Min Zhang #, Hengrui Zhang #, Jie Feng, Yunlong Zhou*, & Bailiang Wang*. Synergistic chemotherapy, physiotherapy and photothermal therapy against bacterial and biofilms infections through construction of chiral glutamic acid functionalized gold nanobipyramids. Chemical Engineering Journal 2020, 393, 124778
[2] Yan Wang , Ningning Bai , Junlong Yang , Zhiguang Liu , Gang Li , Minkun Cai, Lingyu Zhao , Yuan Zhang , Jianming Zhang, Chunhua Li, Yunlong Zhou, Chuan Fei Guo*.Silver nanowires for anti-counterfeiting. Journal of Materiomics 2020, 6, 152e157.

[1] Jun Zhang, Falin Tian, Min Zhang, Tiefeng Li, Xueqian Kong*, Yunlong Zhou*, & Nicholas A. Kotov. Nonsolvent induced reconfigurable bonding configurations of ligands in nanoparticles purification. Nanoscale Horizons 2019, DOI: 10.1039/c9nh00397e.
[2] Limin Chen, Jie Feng, Dan Yang, Falin Tian, Xiaomin Ye, Qiuping Qian, Shuai Wei* & Yunlong Zhou*. Sequence isomerism-dependent self-assembly of glycopeptide mimetics with switchable antibiofilm properties. Chemical Science 2019,10, 8171-8178.
[3] Limin Chen, Dan Yang, Jie Feng, Min Zhang, Qiuping Qian & Yunlong Zhou*. Switchable modulation of bacterial growth and biofilm formation based on supramolecular tripeptide amphiphiles. Journal of Materials Chemistry B 2019, DOI: 10.1039/c9tb00973f ( Emerging Investigators theme).
[4] Limin Chen, Jing Zheng, Jie Feng, Qiuping Qian and Yunlong Zhou*. Reversible modulation of plasmonic chiral signals of achiral gold nanorods using chiral supramolecular template. Chemical Communications 2019, 55, 11378-11381.
[5] Qiuping Qian, Yan Wangc, Min Zhang, Limin Chena, Jie Feng, Yi Wang* & Yunlong Zhou*. Ultrasensitive paper-based polyaniline/graphene composite strain sensor for sign language expression. Composites Science and Technology. 2019,181,107660.
[6] Tao Hu, Jian Xu, Yi Ye, Yu Han, Xiao Li, Zhen Wang, Dongke Sun*, Yunlong Zhou* & Zhonghua Ni*. Visual detection of mixed organophosphorous pesticide using QD-AChE aerogel based microfluidic arrays sensor. Biosensors and Bioelectronics 2019, 136, 112-117.
[7] Ruofei Zhang, Yunlong Zhou, Xiyun Yan & Kelong Fan. Advances in chiral nanozymes: a review. Microchimica Acta 2019, 186, 782.

Before 2019
[1] Yunlong Zhou*, Pablo F. Damasceno, Bagganahalli S. Somashekar, Michael Engel, Falin Tian, Jian Zhu, Rui Huang, Kyle Johnson, Carl McIntyre, Kai Sun, Ming Yang, Peter F. Green, Ayyalusamy Ramamoorthy, Sharon C. Glotzer & Nicholas A. Kotov*. Unusual multiscale mechanics of biomimetic nanoparticle hydrogels. Nature Communications 2018, 9, 181.
[2] Jie Feng, Limin Chen, Yuanzhi Xia, Jie Xing, Zihou Li, Qiuping Qian, Yan Wang, Aiguo Wu, Leyong Zeng & Yunlong Zhou* . Bioconjugation of gold nanobipyramids for SERS detection and targeted photothermal therapy in breast cancer. ACS Biomaterials Science & Engineering 2017, 3, 608-681. (ACS editor’s choice).
[3] Wenliang Gu, Suqin Gong, Yunlong Zhou*, Yunsheng Xia*. Ratiometric sensing of metabolites using dual-emitting ZnS: Mn2+ quantum dots as sole luminophore via surface chemistry design. Biosensors and Bioelectronics 2017, 90,487–493.
[4] Weiwei He, Xiangna Han, Huimin Jia, Junhui Cai, Yunlong Zhou* `& Zhi Zheng. AuPt alloy nanostructures with tunable composition and enzyme like activities for colorimetric detection of bisulfide. Scientific Reports 2017, 7:40103.
[5] Yunlong Zhou & Sharon C. Glotzer* & Nicholas A. Kotov* et al. Biomimetic hierarchical assembly of helical supraparticles from chiral nanoparticles. ACS Nano 2016, 10, 3248−3256.

Wenzhou Institute is a tripartite cooperative institution established by the University of Chinese Academy of Sciences, Wenzhou People’s Government and Wenzhou Medical University in May 2019, which is a secondary college affiliated with University of Chinese Academy of Sciences. The institute is a new type of research institution with core development fields of life and health, medical intelligent equipment, which integrates basic research, achievement transformation and entrepreneurial incubation.

Our research group has been focusing on self-assembly nanomaterials, and interfacial chemical regulatory assembly of nanomaterials.
1) Scientific issues related to the natural property “chirality” of material (including structural chemistry, chiral biocatalysis, and tissue regeneration);
2) The relationship between mechanism of viscoelasticity of self-assembled materials and macroscopic properties;
3) Application of the aforementioned materials in intelligent clinical health monitoring.
Application researches are mainly carried out with clinicians and industrial companies to study the material application in aspects of tissue repair and flexible electronic devices. Our laboratory is equipped with basic analysis equipment, such as gloveboxes, bacterial operation boxes, imported freeze dryers, UV-visible spectrum, and fluorescence spectrum. Since May 2019, our research group and the Wenzhou Institute have entered rapid developed period, and tried to explore basic scientific and technical issues and address clinical problems on the basis of self-assembly chemistry. The research group emphasizes on cooperation and collaboration, and eagerly looks forward to invite domestic and foreign outstanding doctoral students who have research experiences in nanomaterial synthesis and assembly, biomimetic peptide structure and function design, bone tissue and neural tissue regeneration, and flexible electronics. Let us work and live in Wenzhou, a city has beautiful environment of green mountains and clear waters.
Independence, Enthusiasm, Cooperation, Positivity
Assistant researcher: Annual salary (¥18,000-250,000 ) and performance reward  
Postdoctoral fellow: Postdoctoral fellows could work in Wenzhou and cooperate with research groups of University of Chinese Academy of Sciences and enjoy the same treatment as the postdoctoral fellows in Beijing.
A: Annual salary (¥320,000), group subsidy and performance reward
B: Annual salary (¥220,000), group subsidy and performance reward
Upscale housing and housing subsidies

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