WANG Bailiang's group

Dr. Baiiang Wang
Principal Investigator
Wenzhou institute, UCAS

Bailiang Wang is the professor of Wenzhou Institute, University of Chinese Academy of Sciences (WIUCAS) and Eye Hospital, Wenzhou Medical University. He obtained his PhD degree from Zhejiang University under the supervision of Prof. Jian Ji in 2013. In 2018-2019, he worked as a research scholar in Prof. Ali Khademhosseini¢s group in the University of California, Los Angeles. He was promoted to be a professor and PhD supervisor in 2018. His major research interests include advanced ophthalmic biomimetic interface materials and nano-drug carriers. To date, his lab group has published over 60 research papers, including Advanced Materials, ACS Nano,Small, Chemical Engineering Journal, ACS Appl. Mater. Interfaces, Nanoscale, Biomacromolecular, Theranostics, etc (H index=22, citation>1100).

Our research
In recent years, our research group has been focusing on chemical and bio-inspired synthesis of multi-functional biomedical materials, including surface modification of ophthalmic biomaterials, stimulation-responsive ocular drug delivery system and functionalization of nanomaterials. Combined with clinical requirements, we have applied these materials to treat a variety of diseases, such as ophthalmology-related diseases (endophthalmitis, bacterial keratitis, retinal neovascularization, choroidal neovascularization, etc.), bacterial infection (diabetic wound infection, subcutaneous bacterial infection), and ophthalmology-related implant coating materials. Based on the superspreading technique and biomineralization process, we also have demonstrated a facile strategy for fabricating underwater superoleophobic materials with high transparency and mechanical robustness.

Research Topics
1、Development of nanoparticles as drug carriers for improving the penetration of ocular drugs;
2、Biomimetic and functional modification of ophthalmic biomaterial surface;
3、Construction of all-in-one theranostic nanoplatforms for intraocular infection and inflammation;
4、Study on the practicability of low-dimensional nanomaterials in ophthalmology.

Representative Publications
[1] Jie Yang, Dihua Dai, Xinyue Lou, Lianjun Ma, Bailiang Wang*, YingWei Yang*. Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy. Theranostics 2020, 10(2): 615-629.
[2] Wei Chen, Pengchao Zhang, Ruhua Zang, Junbing Fan, Shutao Wang*, Bailiang Wang*, Jingxin Meng*. Nacre-Inspired Mineralized Films with High Transparency and Mechanically Robust Underwater Superoleophobicity. Advanced Materials 2020, 32(11): 1907413.
[3] Min Zhang#, Hengrui Zhang#, Jie Feng, Yunlong Zhou*, Bailiang Wang*. Synergistic chemotherapy,physiotherapy and photothermal therapy against bacterial and biofilms infections through construction of chiral glutamic acid functionalized gold nanobipyramids. Chemical Engineering Journal 2020, 393, 124778.
[4] Hao Chen, Jie Yang, Lin Sun, Hengrui Zhang, Yishun Guo, Jia Qu,* Wenya Jiang, Wei Chen, Jian Ji, YingWei Yang*, Bailiang Wang*. Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework-based Drug Delivery Systems. Small 2019, 15(47): 1903880.
[5] Lin Sun#, Wenya Jiang#, Hengrui Zhang, Yishun Guo, Wei Chen, Yingying Jin, Hao Chen*, Kanghui Du, Hangdong Dai, Jian Ji, Bailiang Wang*. Photosensitizer-Loaded Multifunctional Chitosan Nanoparticles for Simultaneous in Situ Imaging, Highly Efficient Bacterial Biofilm Eradication, and Tumor Ablation. ACS Applied Materials & Interfaces 2018, 11(2): 2302-2316.
[6] Qingwen Xu, Xi Li, Kaihui Nan, Jian Ji, Hao Chen*, Bailiang Wang*. Bacterial self-defense antibiotics release from organic-inorganic hybrid multilayer films for long-term anti-adhesion and biofilm inhibition properties. Nanoscale 2017, 9(48): 19245-19254.
[7] Dengfeng Hu, Huan Li, Bailiang Wang, Zi Ye, Wenxi Lei, Fan Jia, Qiao Jin, Kefeng Ren, Jian Ji*. Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of MRSA Biofilm. ACS Nano 2017, 11(9): 9330-9339.

Other Groups